The changing landscape in translocator protein (TSPO) function
نویسندگان
چکیده
منابع مشابه
An Updated View of Translocator Protein (TSPO)
Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, including cholesterol transport, steroid hormone synthesis, mitochondrial respi...
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Cellular damage and deregulated apoptotic cell death lead to functional impairment, and a main consequence of these events is aging. Cellular damage is initiated by different stress/risk factors such as oxidative stress, inflammation, and heavy metals. These stress/risk factors affect the cellular homeostasis by altering methylation status of several aging and Alzheimer's disease associated gen...
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The translocator protein (TSPO), which was previously designated as the peripheral-type benzodiazepine receptor, is a 3.5 billion year-old evolutionarily conserved protein expressed by most Eukarya, Archae and Bacteria, but its organization and functions differ remarkably. By taking advantage of the genomic data available on TSPO, we focused on bacterial TSPO and attempted to define functions o...
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Translating and translation are transformed with Information and Communication Technology (ICT). Within three decades, a new work environment is shaking up the translator’s world. New types of translators are emerging. The balance between supply and demand is changing. However, we need adequate tools and methods to investigate the new hierarchy which has become established between translators, ...
متن کاملStress sensitivity in patients with atopic dermatitis in relation to the translocator protein 18 kDa (TSPO).
Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by pruritic and eczematous skin lesions and dermatitis that worsens under stressful conditions. However, the relation of these symptoms to an individual's stress sensitivity is not well understood. On the other hand, expression of the translocator protein (18 kDa) (TSPO), formerly known as the peripheral-type benzodiaz...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2015
ISSN: 1043-2760
DOI: 10.1016/j.tem.2015.02.007